关于路德提到的舟山蝙蝠病毒e蛋白基因序列的“常识”
“自然进化过程中，舟山蝙蝠病毒的e蛋白不可能和武汉肺炎病毒的e蛋白拥有完全一致的基因序列”这一条常识，用一些葱油强求的“公理”来说，其实就是种群遗传学里1933年的费雪自然选择基本定理。。https://zh.m.wikipedia.org/wiki/费雪自然选择定理
从蝙蝠宿主到人类宿主这一改变宿主的事实，就是fitness（适应度）的改变，然后方差什么的不用解释了吧。
从蝙蝠宿主到人类宿主这一改变宿主的事实，就是fitness（适应度）的改变，然后方差什么的不用解释了吧。
1 个评论
1. Wuhan seafood market pneumonia virus MN908947
E proteinen / evelope protein (Wuhan seafood market pneumonia virus) QHD43418.1
https://i.imgur.com/YkYDjW6.png
2. Bat SARS-like coronavirus isolate bat-SL-CoVZC45 MG772933.1
E proteinen / evelope protein (bat-SL-CoVZC45) AVP78033.1
3.Journal:
2018 Sep 12 Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135831/
4.BLAST result of QHD43418.1
1: envelope protein [Bat SARS-like coronavirus] 144 144 100% 2e-43 100.00% AVP78033.1
From 2 to 100 are all E protain with score 94.74% ~ 27.79%
https://i.imgur.com/VvX0CZV.png
5. According to the reason of the 发起人DavidteeSlayer , there will be more than one 100% in the 100 samples(actually it's all samples in the database).
6. Host of bat-SL-CoVZC45 is Rhinolophus sinicus (Chinese rufous horseshoe bat).
China studied bat-SL-CoVZC45 in 2018 and published results with full genomes in the journal.
Bats lie dormant in winter.
Wuhan seafood market pneumonia virus is homo SARS virus.
Gene of E protein in each of the viruses is 144/144 same.
中国科学家贺建奎基因编辑婴儿事件 , What is Gene Editing? How does CRISPR/cas9 modify DNA?
醫學倫理學
Wuhan seafood market pneumonia virus is a ssRNA virus, which means it can evolute faster than any of other lives in the earth. And it causes SARS. Anyone with weak immune system is at risk, especially the old and new born babies.
E proteinen / evelope protein (Wuhan seafood market pneumonia virus) QHD43418.1
https://i.imgur.com/YkYDjW6.png
2. Bat SARS-like coronavirus isolate bat-SL-CoVZC45 MG772933.1
E proteinen / evelope protein (bat-SL-CoVZC45) AVP78033.1
3.Journal:
2018 Sep 12 Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135831/
Abstract
SARS coronavirus (SARS-CoV), the causative agent of the large SARS outbreak in 2003, originated in bats. Many SARS-like coronaviruses (SL-CoVs) have been detected in bats, particularly those that reside in China, Europe, and Africa. To further understand the evolutionary relationship between SARS-CoV and its reservoirs, 334 bats were collected from Zhoushan city, Zhejiang province, China, between 2015 and 2017. PCR amplification of the conserved coronaviral protein RdRp detected coronaviruses in 26.65% of bats belonging to this region, and this number was influenced by seasonal changes. Full genomic analyses of the two new SL-CoVs from Zhoushan (ZXC21 and ZC45) showed that their genomes were 29,732 nucleotides (nt) and 29,802 nt in length, respectively, with 13 open reading frames (ORFs). These results revealed 81% shared nucleotide identity with human/civet SARS CoVs, which was more distant than that observed previously for bat SL-CoVs in China. Importantly, using pathogenic tests, we found that the virus can reproduce and cause disease in suckling rats, and further studies showed that the virus-like particles can be observed in the brains of suckling rats by electron microscopy. Thus, this study increased our understanding of the genetic diversity of the SL-CoVs carried by bats and also provided a new perspective to study the possibility of cross-species transmission of SL-CoVs using suckling rats as an animal model.
...
Nucleotide sequence accession numbers
All amplicon sequences and the full genomes of ZXC21 and ZC45 generated in this study have been deposited in GenBank under accession numbers MG772844 through MG772934.
4.BLAST result of QHD43418.1
1: envelope protein [Bat SARS-like coronavirus] 144 144 100% 2e-43 100.00% AVP78033.1
From 2 to 100 are all E protain with score 94.74% ~ 27.79%
https://i.imgur.com/VvX0CZV.png
5. According to the reason of the 发起人DavidteeSlayer , there will be more than one 100% in the 100 samples(actually it's all samples in the database).
6. Host of bat-SL-CoVZC45 is Rhinolophus sinicus (Chinese rufous horseshoe bat).
China studied bat-SL-CoVZC45 in 2018 and published results with full genomes in the journal.
Bats lie dormant in winter.
Wuhan seafood market pneumonia virus is homo SARS virus.
Gene of E protein in each of the viruses is 144/144 same.
中国科学家贺建奎基因编辑婴儿事件 , What is Gene Editing? How does CRISPR/cas9 modify DNA?
醫學倫理學
Wuhan seafood market pneumonia virus is a ssRNA virus, which means it can evolute faster than any of other lives in the earth. And it causes SARS. Anyone with weak immune system is at risk, especially the old and new born babies.
